Iowa State University
College of Human Sciences and College of Agriculture College of Human Sciences College of Agriculture


D. Lee Alekel

  D. Lee Alekel Professor /
Interim Associate Director, NWRC

 

    Education: Ph.D., Nutrition, University of Illinois, 1993

    Interests: The relationship of body composition, physical activity, and nutrient intake to bone mineral density and osteoporotic risk in women; the effect of the menopausal transition and reproductive function/menstrual dysfunction on bone and body composition; and the assessment of nutritional status and body composition in health and disease.

    Office: 1115 Human Nutritional Sciences Building
    Phone: (515) 294-3552
    Fax: (515) 294-5390
    Email: alekel@iastate.edu

Publications:

Books/Book Chapters
  • Alekel DL. Skeletal Effects of Soy Isoflavones in Humans:  Bone Mineral Density and Bone Markers. In:  Handbook of Nutraceuticals and Functional Foods. Second edition. Eds:  Robert E.C. Wildman. CRC Press LLC. 2006.
  • Alekel DL, Matvienko O:  Influence of lifestyle choices on calcium homeostasis:  Smoking, alcohol, and hormone therapies.  Part IV, Chapter 13.  In:  Calcium in Human Health.  First Edition.  CM Weaver, RP Heaney, eds. Humana Press Inc.  Totowa, NJ.  2006.
  • Messina M, Ho S, Alekel DL. Skeletal benefits of soy isoflavones:  A review of the clinical trial and epidemiologic data. Curr Opin Clin Nutr Metab Care 7:649-658, 2004.
  • Birt, D.F., Hendrich, S., Anthony, M. and D.L. Alekel. 2004. Soybeans and the prevention of chronic human disease. Soybeans: Improvement, Production and Uses. J. Specht and R. Boerma, Eds. 3rd edition American Society of Agronomy, Madison WI. pp 1047-1117.
  • Anderson, J.J.B. and D.L. Alekel. 2002. Skeletal Effects of Phytoestrogens in Humans: Bone Mineral Density and Bone Markers. In: GS Gilani GS, Anderson JJB (eds), Phytoestrogens and Health. American Oil Chemists' Society Press, Champaign, IL: pp 341-353.
  • Anthony, M.S., Anderson, J.J.B. and D.L. Alekel. 2002. Association between soy and/or isoflavones and bone: evidence from epidemiologic studies. In: Gilani GS, Anderson JJB (eds), Phytoestrogens and Health. American Oil Chemists' Society Press, Champaign, IL: pp 331-340.
Journal Articles
  • Deardorff B, Alekel DL, Ritland LM, Hanson LN, Genschel U, Reddy MB.  Association among oxidative stress, iron indices, and central adiposity in healthy postmenopausal women.  Journal of Women’s Health. In Press. Anticipated publication:  2009
  • Ritland LM, Alekel DL, Matvienko O, Hanson KB, Stewart JW, Hanson LN, Reddy MB, Van Loan M, Genschel U.  Relationship of centrally-located fat mass and lean mass to circulating leptin, adiponectin, ghrelin, and insulin in healthy postmenopausal women.  Europ J Endocrin 158:889-897, 2008.
  • Perry CD, Alekel DL, Ritland L, Bhupathiraju SN, Stewart JW, Hanson LN, Matvienko O, Kohut M, Reddy MB, Van Loan MD, Genschel U.  Relationship of centrally-located body fat to acute phase proteins and proinflammatory cytokines in healthy postmenopausal women.  Menopause 15(4):619-627, 2008
  • Shedd KM, Hanson KB, Alekel DL, Schiferl DJ, Hanson LN, Van Loan MD. Quantifying leisure physical activity and its relation to bone density and strength.  Med Sci Sports Exerc.  39(12):2189-2198, 2007.
  • Bhupathiraju SN, Alekel DL, Stewart JW, Hanson LN, Shedd KM, Reddy MB, Hanson KB, Van Loan MD, Genschel U, Koehler KJ.  Relationship of circulating total homocysteine and C-reactive protein to trabecular bone in postmenopausal women. J Clin Densit  10(4):395-403, 2007.
  • Engelman* HM, Alekel, D.L., Hanson LN, Kanthasamy AG, Reddy AM. Blood lipid and oxidative stress responses to soy isoflavones and phytic acid in postmenopausal women. Am J Clin Nutr 81:590-596, 2005. [*Barwick as MS student]
  • Zheng, Y.L., Hu, J., Murphy, P.A., Alekel, D.L., Franke, W.D. and S. Hendrich. 2003. Rapid gut transit time and slow fecal isoflavone disappearance phenotype are associated with greater genistein bioavailability in women. J Nutr. 133:3110-3116.
  • Moeller, L.E., Peterson, C.T., Hanson, K.B., Dent, S.B., Lewis, D., King, D. and D.L. Alekel. 2003. Isoflavone-rich soy protein prevents loss of hip lean mass, but does not prevent the shift in regional fat distribution in menopausal women. Menopause. 10(4):322-331.
  • Swain, J.H., Alekel, D.L., Dent, S.B., Peterson, C.T. and M.B. Reddy. 2002. Iron indices and total antioxidant status in response to soy protein intake in perimenopausal women. Am J Clin Nutr. 76:165-171.
  • Alekel, D.L., Peterson, C.T., Werner, R.K., Mortillaro, E., Ahmed, N., and S.C. Kukreja. 2002. Frame size, ethnicity, lifestyle, and biologic contributors to areal and volumetric lumbar spine bone mineral density in Indian/Pakistani and American Caucasian premenopausal women. J Clin Densit 5:175-186.
  • Matvienko, O., Lewis, D.S., Swanson, M., Arndt, B., Rainwater, D.L., Stewart, J.W. and D.L. Alekel. 2002. A single daily dose of soybean plant sterols in ground beef decreases serum total and low-density lipoprotein cholesterol in young mildly hypercholesterolemic men. Am J Clin Nutr. 76:57-64.
  • Dent, S.B., Peterson, C.T., Brace, L.D., Swain, J.H., Reddy, M.B., Hanson, K.B. and D.L. Alekel. 2001. Circulating lipids and lipoproteins or coagulation and fibrinolytic factors do not change in response to soy protein intake in perimenopausal women. J Nutr. 131:2280-2287.
  • St.Germain, A., Peterson, C.T., Robinson, J. and D.L. Alekel. 2001. Effect of isoflavone-rich soy protein isolate on menopausal symptoms in perimenopausal women. Menopause. 8(1):17-26.
  • Alekel, D.L., St.Germain, A., Peterson, C.T., Hanson, K.B., Stewart, J.W. and T. Toda. 2000. Isoflavone-rich soy protein isolate attenuates bone loss in the lumbar spine of perimenopausal women. Am J Clin Nutr. 72:844-852.
  • Alekel, D.L., Mortillaro, E., Hussain, E.A., West, B., Ahmed, N., Peterson, C.T., Werner, R.K., Arjmandi, B.H. amd S.C. Kukreja. 1999. Lifestyle and biologic contributors to proximal femur bone mineral density and hip axis length in two distinct ethnic groups of premenopausal women. Osteoporos Int. 9:327-338.
  • Kamath, S.K., Hussain, E.A., Amin, D., Mortillaro, E., West, B., Peterson, C.T., Aryee, F., Murillo, G. and D.L. Alekel. 1999. Cardiovascular disease risk factors in two distinct ethnic groups: Indian and Pakistani compared with American premenopausal women. Am J Clin Nutr. 69:621-631.
Food Science and Human Nutrition