Diane Birt

Distinguished Professor/Director - Botanical Center
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Education:
Ph.D., Nutrition, Purdue University, 1975
Interests: Identification and study of mechanisms
for cancer prevention by novel dietary constituents and mechanisms
for cancer enhancement by overeating and obesity. Assessment of
potential bioactive and toxic components of botanical dietary supplements
and studies on the mechanism of these effects.
Office: 215 MacKay Hall
Phone: (515) 294-9873
Fax: (515) 294-6193
Email: dbirt@iastate.edu
Center
for Research on Botanical Dietary Supplements 2004
Presidential Lecture - "Is Cancer Preventable?"
- Power Point Presentation
- Audio
File
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Publications:
- LaLone, C.A., Hammer, K.D.P., Wu, L., Bae J., Leyva, N., Liu, Y., Solco, A.K.S., George A. Kraus, G.A., Murphy, P.A., Wurtele, E.S.,Kim, O-K, Seo, K., Widrlechner, M.P., and Birt, D.F. Echinacea Species and Alkamides Inhibit Prostaglandin E2 Production in RAW264.7 Mouse Macrophage Cells. J. Agriculture and Food Chemistry, 55:7314-7322, 2007. On line at http://pubs.acs.org/cgi-bin/abstract.cgi/jafcau/2007/55/i18/abs/jf063711a.html
- Hammer, K.D.P., Hillwig, M.L., Solco, A.K.S., Dixon, P.M., Delate, K., Murphy, P.A., Wurtele, E.S., and Birt, D.F. Inhibition of PGE2 Production by Anti-Inflammatory Hypericum perforatum Extracts and Constituents in RAW264.7 Mouse Macrophage Cells. J. Agriculture and Food Chemistry, 55:7323 -7331 2007. On line at http://pubs.acs.org/cgi-bin/abstract.cgi/jafcau/2007/55/i18/abs/jf0710074.html
- McGinnis, J.M., Birt, D.F., Brannon, P.M., Carroll, R.J., Gibbons, R.D., Hazzard, W.R., Kamerow, D.B., Levin, B., Ntambi, J.M., Paneth, N., Rogers, D., Saftlas, A.F., and Vaughan, W. National institutes of health state-of-the-science conference statement: Multivitamin/mineral supplements and chronic disease prevention. Amer.J.Clin.Nutr., 85, 257S-264S. 2007
- Kineman, B.D., Au, A., Paiva, N., Kaiser, M.S., Brummer, E.C., and Birt, D.F.Transgenic Alfalfa that accumulates Piceid (trans-resveratrol-3-O-β-D-glucopyranoside) requires the presence of β-glucosidase to inhibit the formation of Aberrant Crypt Foci in the colon of CF-1 mice.Nutrition and Cancer, 58, 66-74. 2007
- Chung, C.S., Cheng, D. and Birt, D.F. Impact of adenomatous polyposis coli (apc) tumor supressor gene in human colon cancer cell lines on cell cycle arrest by apigenin. Molecular Carcinogenesis, In Press 2007.
- Birt, D. F. 2006 Phytochemicals and Cancer Prevention: From Epidemiology to Mechanism of Action. Journal of the American Dietetic Association 106(1): 20-21.
- Schmitt, L.A., Liu, Y., Murphy, P.A., Petrich, J.W., Dixon, P.M. and Birt, D.F. 2006 Reduction in Hypericin-Induced Phototoxicity by Hypericum perforatum Extracts and Pure Compounds. J Photochemistry and Photobiology B.Biology, 85:118-130.
- Schmitt, L.A., Liu, Y., Murphy, P.A., and Birt, D.F. 2006. Evaluation of the Light-Sensitive Cytotoxicity of Hypericum perforatum Extracts, Fractions, and Pure Compounds. J. Ag and Food Chem. 54 (8), 2881 -2890. On line at http://dx.doi.org/10.1021/jf052344k
- Angela Au, Boyong Li, Weiqun Wang, Hemant Roy, Ken Koehler, Birt, D.F. 2006 The effect of dietary apigenin on colonic ornithine decarboxylase activity, aberrant crypt foci formation and tumorigenesis in different experimental models. Nutrition and Cancer. 54:243-251.
- Stewart, J.W., Koehler, K., Jackson, W., Hawley, J., Wang, W., Au,
A., Myers, R. and D.F. Birt. 2005. Prevention of mouse skin tumor promotion
by dietary energy restriction requires an intact adrenal gland and glucocorticoid
supplementation restores inhibition. Carcinogenesis, 26:1077-1084. (PDF file)
- Wang, W., VanAlstyne, P.C., Irons, K.A., Chen, S., Stewart, J.W. and
D.F. Birt. 2004. Individual and Interactive Effect of Apigenin Analogues
on G2/M Cell Cycle Arrest in Human Colon Carcinoma Cell lines. Nutrition
and Cancer, 48:106-114. (PDF file)
- Birt, D.F., Hendrich, S., Anthony, M. and D.L. Alekel. 2004. Soybeans
and the prevention of chronic human disease. Soybeans: Improvement,
Production and Uses. J. Specht and R. Boerma, Eds. 3rd edition American
Society of Agronomy, Madison, WI: pp 1047-1117. (PDF file)
- Birt, D.F., Przybyszewski, J., Wang, W., Stewart J.W. and Y. Liu.
2004. Identification of molecular targets for dietary energy restriction
prevention of skin carcinogenesis: An idea cultivated by Edward Bresnick.
J. Cellular Biochemistry. 91:258-264. (PDF file)
- Birt, D.F., Wang, W., Paiva, N., Au, A., Chung, C., Schmitt, L. and
Y. Jiang. 2004. Cancer prevention by phytochemicals, modulation of cell
cycle. In: Phytochemicals: Mechanisms of Action M.S. Meskin, W.R. Bidlack,
A.J. Davies, D.S. Lewis; R.K. Randolph Eds. CRC Press, Washington, D.C.:
pp 61-77. (PDF file)
- Lee, C.J., Birt, D.F., Kirksey, A. and C. Weaver. 2003. Helen E. Clark
(1912-2001) J. Nutr. 133:1773-1775.
- Liu., Y, Wang, W., Hawley, J. and D.F. Birt. 2002. Adrenalectomy abrogates
reduction of TPA-induced ERK activity in the epidermis of dietary energy
restricted SENCAR mice: Implications of glucocorticoid hormone. Cancer
Epidemiology, Biomarkers and Prevention. 11: 299-304. (PDF file)
- Przybyszewski, J., Yaktine, A.L., Duysen, E., Blackwood, D., Wang,
W., Au, A. and D.F. Birt. 2001. Inhibition of Epidermal c-Jun Protein,
m-RNA and AP-1:DNA Binding by 40% Energy Restriction is Reversed by
Adrenalectomy in the SENCAR Mouse. Carcinogenesis. 22:1421-1427. (PDF file)
- Liu,Y., Duysen. E., Yaktine, A.L., Au, A., Wang, W. and D.F. Birt.
2001. Dietary Energy Restriction Inhibits ERK but not JNK or p38 activity
in the epidermis of SENCAR Mice, Carcinogenesis. 22: 607-612. (PDF file)
- Birt, D.F., Duysen, E., Wang, W. and A. Yaktine. 2001. Corticosterone
supplementation reduced selective protein kinase C isoform expression
in the epidermis of adrenalectomized mice. Cancer Epidemiology, Biomarkers
and Prevention, 10: 679-685. (PDF file)
- Messina, M., Lampe, J.W., Birt, D.F., Appel, L.J., Pivonka, E., Berry,
B. and D.R. Jacobs. 2001. Reductionisn and the narrowing nutrition perspective:
Time for reevaluation and emphasis on food synergy. J. Amer. Dietetic
Assn. 101:1416-1419.
- D.F. Birt. 2001. Soybeans and cancer prevention: a complex food and
a complex disease. In Nutrition and Cancer Prevention: New Insights
into the role of phytochemicals. Kluwer Academic Press/Plenum Publishers,
New York, NY: pp 1-10.
- Harvell, D.M.E., Spady, T.J., Strecker, T.E.,Lemus-Wilson, A.M., Pennington,
K.L., Shen, F., Birt, D.F., McComb, R.D. and J.D. Shull. 2001. Dietary
energy restriction inhibits estrogen induced pituitary tumorigenesis
in a rat strain specific manner. Hormonal Carcinogenesis III, Springer-Verlag,
New York, NY: pp 496-501.
- Birt, D.F., Hendrich, S. and W. Wang. 2001. Dietary agents in Cancer
prevention: flavonoids and isoflavonoids. Pharmacology and Therapeutics.
90:157-177. (PDF file)
- Wang, W., Heideman, L., Chung, C., Pelling, J.C., Koehler, K.J. and
D.F. Birt. 2000. Cell cycle arrest at G2/M and growth inhibition by
apigenin in human colon carcinoma cell lines. Molecular Carcinogenesis.
28:102-110. (PDF file)
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