Michael Spurlock
Professor
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Education: Ph.D. Nutrition, University of Missouri
Interests: The mechanisms underlying inflammation
in adipose tissue and insulin resistance in relation to obesity.
Office: 1109 HNSB
Phone: (515) 294-5038
Fax: (515) 294-6193
Email: mspurloc@iastate.edu
Research
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Publications:
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Gabler NK, Radcliffe JS, Spencer JD, Webel DM, Spurlock ME.Feeding long-chain n-3 polyunsaturated fatty acids during gestation increases intestinal glucose absorption potentially via the acute activation of AMPK. J Nutr Biochem. 2008 May 12. [Epub ahead of print] PMID: 18479897 [PubMed - as supplied by publisher]
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Davis JE, Gabler NK, Walker-Daniels J, Spurlock ME. Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat. Obesity (Silver Spring). 2008 Jun;16(6):1248-55. Epub 2008 Apr 10.PMID: 18421279 [PubMed - in process]
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Spurlock ME, Gabler NK. The development of porcine models of obesity and the metabolic syndrome.
J Nutr. 2008 Feb;138(2):397-402. PMID: 18203910 [PubMed - indexed for MEDLINE]
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Gabler NK, Spencer JD, Webel DM, Spurlock ME. In utero and postnatal exposure to long chain (n-3) PUFA enhances intestinal glucose absorption and energy stores in weanling pigs. J Nutr. 2007 Nov;137(11):2351-8. PMID: 17951469 [PubMed - indexed for MEDLINE]
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Gabler NK, Spurlock ME. Integrating the immune system with the regulation of growth and efficiency.
J Anim Sci. 2008 Apr;86(14 Suppl):E64-74. Epub 2007 Oct 2. Review. PMID: 17911231 [PubMed - indexed for MEDLINE]
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Gabler NK, Spencer JD, Webel DM, Spurlock ME. n-3 PUFA attenuate lipopolysaccharide-induced down-regulation of toll-like receptor 4 expression in porcine adipose tissue but does not alter the expression of other immune modulators. J Nutr Biochem. 2008 Jan;19(1):8-15. Epub 2007 Apr 16.
PMID: 17434724 [PubMed - indexed for MEDLINE]
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Jacobi SK, Gabler NK, Ajuwon KM, Davis JE, Spurlock ME. Adipocytes, myofibers, and cytokine biology: new horizons in the regulation of growth and body composition. J Anim Sci. 2006 Apr;84 Suppl:E140-9. Review. PMID: 16582086 [PubMed - indexed for MEDLINE]
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Ajuwon KM, Spurlock ME. Palmitate activates the NF-kappaB transcription factor and induces IL-6 and TNFalpha expression in 3T3-L1 adipocytes. J Nutr. 2005 Aug;135(8):1841-6.
PMID: 16046706 [PubMed - indexed for MEDLINE]
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Ajuwon KM, Spurlock ME. 2005. Adiponectin inhibits LPS-induced NF-kappaB activation and IL-6 production and increases PPARgamma2 expression in adipocytes. Am J Physiol Regul Integr Comp Physiol. 2005 May;288(5):R1220-5. Epub 2004 Dec 16. PMID: 15604306 [PubMed - indexed for MEDLINE]
- Wulster-Radcliffe, M.C.* and Spurlock, M.E.*, 2005. Adiponectin
suppresses proliferation and proinflammatory cytokine production in
THP-1 monocytes, and induces caspase 3/7 activity. Adipocytes 1:35-42.
- Ajuwon, K.M.* and Spurlock, M.E.*, 2005. Palmitate activates the
nuclear factor kappa-B transcription factor and induces IL-6 and TNFα
production in 3T3-L1 adipocytes. J. Nutr. 135:1841-1846.
- Ajuwon KM, Spurlock ME. Palmitate
activates the NF-kappaB transcription factor and induces IL-6 and
TNFalpha expression in 3T3-L1 adipocytes. J Nutr. 2005 Aug;135(8):1841-6.
PMID: 16046706 [PubMed - in process]
- Ajuwon KM, Spurlock ME. Adiponectin
inhibits LPS-induced NF-kappaB activation and IL-6 production and
increases PPARgamma2 expression in adipocytes. Am J Physiol Regul
Integr Comp Physiol. 2005 May;288(5):R1220-5. Epub 2004 Dec 16. PMID:
15604306 [PubMed - indexed for MEDLINE]
- Jacobi SK, Ajuwon KM, Weber TE, Kuske JL, Dyer CJ, Spurlock ME.
Cloning
and expression of porcine adiponectin, and its relationship to adiposity,
lipogenesis and the acute phase response. J Endocrinol. 2004 Jul;182(1):133-44.
PMID: 15225138 [PubMed - indexed for MEDLINE]
- Weber TE, Spurlock ME. Leptin
alters antibody isotype in the pig in vivo, but does not regulate
cytokine expression or stimulate STAT3 signaling in peripheral blood
monocytes in vitro. J Anim Sci. 2004 Jun;82(6):1630-40. PMID:
15216988 [PubMed - indexed for MEDLINE]
- Ajuwon KM, Spurlock ME. Direct
regulation of lipolysis by interleukin-15 in primary pig adipocytes.
Am J Physiol Regul Integr Comp Physiol. 2004 Sep;287(3):R608-11. Epub
2004 May 20. PMID: 15155279 [PubMed - indexed for MEDLINE]
- Wulster-Radcliffe MC, Ajuwon KM, Wang J, Christian JA, Spurlock
ME. Adiponectin
differentially regulates cytokines in porcine macrophages. Biochem
Biophys Res Commun. 2004 Apr 9;316(3):924-9. PMID: 15033490 [PubzMed
- indexed for MEDLINE]
- Ajuwon KM, Jacobi SK, Kuske JL, Spurlock ME. Interleukin-6
and interleukin-15 are selectively regulated by lipopolysaccharide
and interferon-gamma in primary pig adipocytes. Am J Physiol Regul
Integr Comp Physiol. 2004 Mar;286(3):R547-53. Epub 2003 Dec 4. PMID:
14656772 [PubMed - indexed for MEDLINE]
- Ajuwon KM, Kuske JL, Anderson DB, Hancock DL, Houseknecht KL, Adeola
O, Spurlock ME. Chronic
leptin administration increases serum NEFA in the pig and differentially
regulates PPAR expression in adipose tissue. J Nutr Biochem. 2003
Oct;14(10):576-83. PMID: 14559108 [PubMed - indexed for MEDLINE]
- Raman P, Donkin SS, Spurlock ME. Regulation
of hepatic glucose metabolism by leptin in pig and rat primary hepatocyte
cultures. Am J Physiol Regul Integr Comp Physiol. 2004 Jan;286(1):R206-16.
Epub 2003 Sep 25. PMID: 14512272 [PubMed - indexed for MEDLINE]
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